The Possible Involvement of Protozoans in Causing Cancer in Human

Egyptian Academic Journal of Biological Sciences E Medical Entomology and Parasitology Pub Date : 2022-04-18 DOI:10.21608/eajbse.2022.231586

M. Salim, Masroor, Mohammad Shahid, Parween, Shagufta

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引用次数: 2

Abstract

protozoans have also been found to cause cancer in humans and animals. They are eukaryotic, unicellular, anthropozoonotic microorganisms causing several life-threatening diseases and cancer in humans. While a plethora of good pieces of information was gathered while documenting the role of several protozoans causing cancer in humans, only Plasmodium falciparum has been categorized by the IARC as Group 2A carcinogen. However, certain other protozoan parasites have also got their ability to cause cancer in humans via the integration of protozoan DNA sequences in the host cells. Protozoans cause the stimulation of cell division and proliferation of the host cells by the release of reactive oxygen and nitrogen radicals, DNA damage and the p53 gene inhibition. The present review discusses some cancer-causing protozoan parasites like Leishmania donovani, Trypanosoma brucie, Toxoplasma gondii, Trichomonas vaginalis, Blastocystis hominis, Theileria microti and Cryptosporidium parvum including Plasmodium falciparum in the light of recent researches done so far in the field of microbial origin of cancer.

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原生动物引起人类癌症的可能参与

原生动物也被发现会导致人类和动物的癌症。它们是真核的、单细胞的、人畜共患的微生物，引起人类几种危及生命的疾病和癌症。虽然在记录几种导致人类癌症的原生动物的作用时收集了大量有用的信息，但只有恶性疟原虫被国际癌症研究机构归类为2A类致癌物。然而，某些其他原生动物寄生虫也通过整合宿主细胞中的原生动物DNA序列而获得了导致人类癌症的能力。原生动物通过释放活性氧和氮自由基、损伤DNA和抑制p53基因等途径刺激宿主细胞分裂和增殖。本文结合近年来在癌症微生物起源领域的研究进展，综述了多诺瓦利什曼原虫、布鲁氏锥虫、刚地弓形虫、阴道毛滴虫、人芽囊虫、微孢子虫、小隐孢子虫等致癌性原生动物寄生虫，包括恶性疟原虫。

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Egyptian Academic Journal of Biological Sciences E Medical Entomology and Parasitology

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