Protective effect of allopurinol in the renal ischemia–reperfusion in uninephrectomized rats

Abstract

The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfunction, and histologic alterations was evaluated during the renal ischemia–reperfusion in uninephrectomized rats. Renal malondialdehyde and serum creatinine levels significantly increased after renal ischemia–reperfusion. However, the pretreatment with allopurinol demonstrated a protector effect in these parameters. Renal ischemia–reperfusion provoked a significant renal damage in the operated group. Tubular atrophy and interstitial fibrosis were attenuated by allopurinol when given prior to the surgery. In our study, allopurinol had a strong tendency to exert a beneficial effect during renal ischemia–reperfusion in uninephrectomized rats.