Synthesis of Some Unsymmetrical Ester Derivatives of γ-(4-Substituted piperazin-1-yl)-α-phenyl propanols with Antispasmodic Activity

Abstract

Six new ester derivatives of γ-(4-substituted piperazinyl)-α-phenyl propanol were prepared by esterification of the γ-piperazinyl propanols. The derivatives were methyl, ethyl, phenyl and benzyl esters, and they were obtained in good yields using a solid-liquid phase transfer catalysed esterification method. The nitrogen content of the new derivatives was also determined. Studies using isolated guineapig ileum showed that the derivatives possessed varying degrees of antispasmodic activity. Of the compounds evaluated, the ethyl ester of γ-(4-benzyl piperazin-1-yl)-α-phenyl propanol showed the greatest antispasmodic activity.