{"title":"Effect of Quinone Derivatives on Ethanol and Acetaldehyde Metabolism in Rats","authors":"N. Hobara, A. Watanabe, Y. Gomita, Y. Araki","doi":"10.5649/jjphcs1975.15.33","DOIUrl":null,"url":null,"abstract":"Quinone derivatives, such as 2, 3-dimethoxy-5-methy1-6-decapreny1-1, 4-benzoquinone (ubidecarenone, coenzyme Q10, CoQ10), 4, 5-dihydro-4, 5-dioxo-1H-pyrrolo [2, 3-f] quinoline-2, 7, 9-tricarboxylic acid (pyrroloquinoline quinone, PQQ) and 6-(10-hydroxydecy1)-2, 3-dimethoxy-5-methy1-1, 4-benzoquinone (idebenone), significantly inhibited rise of acetaldehyde concentration in blood and liver of rats following ethanol ingestion.Acetaldehyde concentrations decreased in vitro with incubation with 1, 4-benzoquinone or PQQ solution at 40°C. Low acetaldehyde concentrations following ethanol ingestion might be due to PQQ-accelerated oxidation of acetaldehyde.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"7 1","pages":"33-35"},"PeriodicalIF":0.0000,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Nippon Hospital Pharmacists Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5649/jjphcs1975.15.33","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Quinone derivatives, such as 2, 3-dimethoxy-5-methy1-6-decapreny1-1, 4-benzoquinone (ubidecarenone, coenzyme Q10, CoQ10), 4, 5-dihydro-4, 5-dioxo-1H-pyrrolo [2, 3-f] quinoline-2, 7, 9-tricarboxylic acid (pyrroloquinoline quinone, PQQ) and 6-(10-hydroxydecy1)-2, 3-dimethoxy-5-methy1-1, 4-benzoquinone (idebenone), significantly inhibited rise of acetaldehyde concentration in blood and liver of rats following ethanol ingestion.Acetaldehyde concentrations decreased in vitro with incubation with 1, 4-benzoquinone or PQQ solution at 40°C. Low acetaldehyde concentrations following ethanol ingestion might be due to PQQ-accelerated oxidation of acetaldehyde.
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