A. Hoxha, D. Gillam, A. Bushby, Amani Agha, Mangala Patel
{"title":"Layered Double Hydroxide Fluoride Release in Dental Applications: A Systematic Review","authors":"A. Hoxha, D. Gillam, A. Bushby, Amani Agha, Mangala Patel","doi":"10.3390/dj7030087","DOIUrl":null,"url":null,"abstract":"This systematic review appraises studies conducted with layered double hydroxides (LDHs) for fluoride release in dentistry. LDH has been used as antacids, water purification in removing excess fluoride in drinking water and drug delivery. It has great potential for controlled fluoride release in dentistry, e.g., varnishes, fissure sealants and muco-adhesive strips, etc. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement was followed with two reviewers performing a literature search using four databases: PubMed, Web of Science, Science Direct and Ovid Medline with no date restrictions. Studies including any LDH for ion/drug release in dentistry were included, while assessing the application of LDH and the value of the methodology, e.g., ion release protocol and the LDH production process. Results: A total of 258 articles were identified and four met the inclusion criteria. Based on two in vitro studies and one clinical study, LDH was previously studied in dental materials, such as dental composites and buccal muco-adhesive strips for fluoride release, with the latter studied in a clinical environment. The fourth study analysed LDH powder alone (without being incorporated into dental materials). It demonstrated fluoride release and the uptake of volatile sulphur compounds (VSC), which may reduce halitosis (malodour). Conclusion: LDHs incorporated in dental materials have been previously evaluated for fluoride release and proven to be clinically safe. LDHs have the potential to sustain a controlled release of fluoride (or other cariostatic ions) in the oral environment to prevent caries. However, further analyses of LDH compositions, and clinical research investigating any other cariostatic effects, are required.","PeriodicalId":47284,"journal":{"name":"Open Dentistry Journal","volume":"122 1","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Dentistry Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/dj7030087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 11
Abstract
This systematic review appraises studies conducted with layered double hydroxides (LDHs) for fluoride release in dentistry. LDH has been used as antacids, water purification in removing excess fluoride in drinking water and drug delivery. It has great potential for controlled fluoride release in dentistry, e.g., varnishes, fissure sealants and muco-adhesive strips, etc. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement was followed with two reviewers performing a literature search using four databases: PubMed, Web of Science, Science Direct and Ovid Medline with no date restrictions. Studies including any LDH for ion/drug release in dentistry were included, while assessing the application of LDH and the value of the methodology, e.g., ion release protocol and the LDH production process. Results: A total of 258 articles were identified and four met the inclusion criteria. Based on two in vitro studies and one clinical study, LDH was previously studied in dental materials, such as dental composites and buccal muco-adhesive strips for fluoride release, with the latter studied in a clinical environment. The fourth study analysed LDH powder alone (without being incorporated into dental materials). It demonstrated fluoride release and the uptake of volatile sulphur compounds (VSC), which may reduce halitosis (malodour). Conclusion: LDHs incorporated in dental materials have been previously evaluated for fluoride release and proven to be clinically safe. LDHs have the potential to sustain a controlled release of fluoride (or other cariostatic ions) in the oral environment to prevent caries. However, further analyses of LDH compositions, and clinical research investigating any other cariostatic effects, are required.
本系统综述评价了使用层状双氢氧化物(LDHs)进行的牙科氟化物释放研究。LDH已被用作抗酸剂、水净化、去除饮用水中过量的氟化物和药物输送。它有很大的潜力控制氟化物释放在牙科,如清漆,裂缝密封剂和粘粘条等。根据系统评价和荟萃分析的首选报告项目(PRISMA)声明,两位审稿人使用四个数据库进行文献检索:PubMed、Web of Science、Science Direct和Ovid Medline,没有日期限制。包括LDH在牙科离子/药物释放方面的研究,同时评估LDH的应用和方法的价值,例如离子释放方案和LDH生产工艺。结果:共筛选到258篇文献,其中4篇符合纳入标准。基于两项体外研究和一项临床研究,LDH先前在牙科材料中进行了研究,如牙科复合材料和口腔粘膜粘接条,用于氟释放,后者在临床环境中进行了研究。第四项研究单独分析了LDH粉(未掺入牙科材料中)。它显示氟化物释放和挥发性硫化合物(VSC)的吸收,这可能会减少口臭(恶臭)。结论:先前对牙科材料中掺入的LDHs进行了氟化物释放评估,并被证明是临床安全的。LDHs有可能在口腔环境中维持氟化物(或其他防龋离子)的可控释放,以预防龋齿。然而,还需要进一步分析LDH的组成,并进行临床研究来调查任何其他的固牙作用。