Spectrophotometric determination and estimation of minoxidil in tablet dosage form by UV

S. Khadeerunnisa, T. Vimalakkannan, T. Lakshmi
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引用次数: 1

Abstract

A simple, precise, accurate and economical UV spectrophotometric method has been developed and validated for the estimation of Minoxidil in the tablet dosage form. Minoxidil shows maximum absorbance at 279.4nm. The method was carried out by using 0.1N HCl as a solvent. The drug shows linearity from the concentration range of 1-6µg/ml and correlation coefficient was found to be 0.9992. The proposed method was statistically validated for precision, accuracy, ruggedness, robustness, the limit of detection, quantitation as per the ICH guidelines. Hence this method can be successfully applied for routine analysis of Minoxidil in bulk and tablet dosage form.
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紫外分光光度法测定片剂中米诺地尔的含量
建立了一种简便、精确、准确、经济的米诺地尔片剂紫外分光光度法。米诺地尔在279.4nm处显示最大吸光度。该方法以0.1盐酸为溶剂进行。在1 ~ 6µg/ml浓度范围内呈线性关系,相关系数为0.9992。根据ICH指南对该方法的精密度、准确度、坚固性、稳健性、检出限和定量进行了统计验证。该方法可用于米诺地尔原料药和片剂的常规分析。
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