The use of vector formalism in the analysis of hydrophobic and electric driving forces in biological assemblies.

IF 23.1 1区 医学 Q1 HEMATOLOGY Blood Pub Date : 2022-04-11 DOI:10.1017/S0033583522000038
Angel Mozo-Villarías, Juan A Cedano, Enrique Querol
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利用矢量形式分析生物组装中的疏水和电驱动力。
疏水力不仅在蛋白质的三维结构构象中起着至关重要的作用,而且在dna -蛋白质复合物的形成中也起着至关重要的作用。在大分子结合的三级和四级结构中,电场也起着重要的作用。有时,疏水和电相互作用叠加在一起,形成这些结构,但在大多数情况下,它们的作用方向相反。这一事实,以及与不同范围的整体相互作用,提供了一种微妙的平衡,也通过需要遵守空间障碍和几何挫折效应来调节。本文主要介绍了利用疏水偶极矩和电偶极矩矢量来描述生物大分子结构的相互作用。虽然在文献中描述了电偶极矩和疏水矩的不同定义,但在生物组装中获得的结果证明了生物膜模型的原理。根据这个模型,我们的团队假设,生物大分子倾向于通过排列它们的疏水时刻以类似于膜中的磷脂的方式结合。封闭和开放结构的例子被用来评估我们模型的可预测性。我们寻求我们的结果与当前文献中描述的结果一致。回顾以使用这种形式对未来可能的预测作为结束。
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来源期刊
Blood
Blood 医学-血液学
CiteScore
23.60
自引率
3.90%
发文量
955
审稿时长
1 months
期刊介绍: Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.
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