Recent Advances in Natural Plant-based Treatment of Myocardial Ischemia-reperfusion Injury

Peixun Yang, Minxuan Liu, Xiaoxue Fan, Xinzhuang Zhang, Liang Cao, Zhenzhong Wang, W. Xiao
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Abstract

Review Recent Advances in Natural Plant-based Treatment of Myocardial Ischemia-reperfusion Injury Peixun Yang 1,3,4, Minxuan Liu 2,3,4, Xiaoxue Fan 3,4, Xinzhuang Zhang 3,4, Liang Cao 3,4, Zhenzhong Wang 3,4, and Wei Xiao 3,4, * 1 Kanion School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Avenue Qixia District, Nanjing 210046, China 2 School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue Qixia District, Nanjing 210046, China 3 National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Jiangning Industrial City, Economic and Technological Development Zone of Lianyungang, Lianyungang 222001, China 4 Jiangsu Kanion Pharmaceutical Co Ltd, Jiangning Industrial City, Economic and Technological Development Zone of Lianyungang, Lianyungang 222001, China * Correspondence: xw_kanion@163.com ( Wei Xiao)     Received: 23 March 2023 Accepted: 10 May 2023   Abstract: Cardiovascular disease (CDV) is the primary cause of death in the world, and myocardial ischemia (MI) is one of the high-risk CVDs. The myocardial blood supply must be restored as soon as possible to reduce the mortality risk, however, reperfusion itself paradoxically leads to further death of cardiomyocytes and increases the infarct size; this is known as myocardial ischemia/reperfusion injury (MIRI). The pathological mechanism of MIRI is complex, and current research mainly focuses on oxidative stress, dysfunctional mitochondrial energy metabolism, Ca 2+ overload, endoplasmic reticulum stress (ERs) and the inflammatory response. This review briefly summarizes the mechanism of MIRI, and natural plant product (NPP) components proven to ameliorate MIRI and their related signaling pathways. NPPs can alleviate MIRI by regulating oxidative stress, inflammation, ERs, Ca 2+ overload and mitochondrial function maintenance. This review will deepen our understanding of how NPPs reduce MIRI and the future value of NPPs in cardio-protection.
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天然植物治疗心肌缺血再灌注损伤的研究进展
天然植物治疗心肌缺血再灌注损伤的研究进展[杨培勋1,3,4,刘敏轩2,3,4,樊晓雪3,4,张新庄3,4,曹亮3,4,王振忠3,4,肖伟3,4]*1南京中医药大学康宁中药学院,南京栖霞区仙林大道138号,210046;2南京中医药大学药学院,南京栖霞区仙林大道138号,210046;3连云港经济技术开发区江宁工业城,连云港222001;4连云港经济技术开发区江宁工业城,江苏康宁药业有限公司,连云港222001 *通讯:xw_kanion@163.com(魏晓)摘要:心血管疾病(CDV)是全球死亡的首要原因,心肌缺血(MI)是高危心血管疾病之一。心肌血供必须尽快恢复,以降低死亡风险,然而,再灌注本身矛盾地导致心肌细胞进一步死亡并增加梗死面积;这被称为心肌缺血/再灌注损伤(MIRI)。MIRI的病理机制复杂,目前的研究主要集中在氧化应激、线粒体能量代谢功能障碍、ca2 +超载、内质网应激(endoplasmic reticulum stress, ERs)和炎症反应等方面。本文就MIRI的作用机制、已证实改善MIRI的天然植物产物(natural plant product, NPP)成分及其相关信号通路作一综述。核电厂可通过调节氧化应激、炎症、内质网、ca2 +超载和线粒体功能维持来缓解MIRI。这篇综述将加深我们对NPPs如何降低MIRI以及NPPs在心脏保护中的未来价值的理解。
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