Antibacterial Kaolinite Based Nanocomposites

Abstract

In this study we focused on antimicrobial nanocomposites based on kaolinite, when two series of nanocomposites were prepared. In the first case, kaolinite (KAO) was used as the carrier for antibacterial drug. Secondly, kaolinite modified with dimethyl sulphoxide (DMSO) was used. In both series, chlorhexidine dihydrochloride (CH) acts as an active antimicrobial component. The resultant samples were characterized by X – ray diffraction (XRD) and infrared spectroscopy (FTIR). The antimicrobial activity of prepared composites against bacteria strains Staphylococcus aureus, Escherichia coli and against yeast Candida albicans were evaluated by finding minimum inhibitory concentration (MIC). It was found that prepared nanocomposites were very effective and they had different effect against bacteria strains and yeast. Important information was that treatment with DMSO had not significant effect on antimicrobial activity. These nanocomposites can be in future used for preparation of drugs for local treatment of oral cavity with long-acting antimicrobial activity.