Relationship between Serum Trough Concentrations of Cibenzoline and Fasting Blood Glucose Levels in Inpatiens Received Cibenzoline Therapy.

Abstract

The relationship between the serum trough concentrations of cibenzoline and the fasting blood glucose (FBG) levels were evaluated in 78 inpatients received cibenzoline therapy. As a result, as the serum trough concentrations of cibenzoline increased, the FBG levels decreased in inverse proportion. The FBG levels after the administration of cibenzoline decreased significantly (P<0.01) more than before administration. In addition, when the serum cibenzoline concentrations were higher the FBG levels also decreased significantly (P<0.01) more than when the serum concentrations were lower. The mean serum concentration when the FBG levels were less than 80mg/dL was higher than that when the FBG levels were lover 90mg/dL (383±273 vs 284±189ng/mL, P<0.071). These results suggest that more careful monitoring of the side effects of cibenzoline caused by a decrease in the FBG is thus needed in patients receiving cibenzoline therapy.