Hepatic antioxidant and gut ecological modulation properties of long-term intake of tea (Camellia sinensis L.) flower extract in vivo

Dan Chen, Jialiang Lv, Tao Han, Juan Kan, Changhai Jin, Jun Liu
{"title":"Hepatic antioxidant and gut ecological modulation properties of long-term intake of tea (Camellia sinensis L.) flower extract in vivo","authors":"Dan Chen, Jialiang Lv, Tao Han, Juan Kan, Changhai Jin, Jun Liu","doi":"10.15586/qas.v15i3.1209","DOIUrl":null,"url":null,"abstract":"Tea (Camellia sinensis L.) flower extract (TFE) is a new type of tea beverage. The aim of this study was to explore the possible function after intake of TFE for a fixed period. In the study, 200 mg/kg body weight (BW)/day (d) of TFE was given to mice for 14 weeks. The results showed that the levels of hepatic superoxide dismutase and reduced glutathione were increased but the formation of malondialdehyde was reduced, compared to the normal control (NC) group. Meanwhile, administration of TFE contributed to the prior number of colonic goblet cells (1,505 ± 124 vs. 1,162 ± 112, per mm2) and enhancement of colonic messenger RNA expression of mucin 2 and Claudin5. Additionally, TFE intervention modulated the composition and metabolic pathways of gut microbiota with an important role in dietary metabolism. Representatively, the relative abundance of genera Bacteroides, Prevotella, and Lachnospiracea_incertae_sedis, and the levels of short-chain fatty acids (SCFAs) and immunoglobulin A were increased. Taken together, long-term intake of TFE could promote hepatic antioxidant and modulate gut ecological status. These results could provide a reference for the development of TFE as a functional beverage.","PeriodicalId":20738,"journal":{"name":"Quality Assurance and Safety of Crops & Foods","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Quality Assurance and Safety of Crops & Foods","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15586/qas.v15i3.1209","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Tea (Camellia sinensis L.) flower extract (TFE) is a new type of tea beverage. The aim of this study was to explore the possible function after intake of TFE for a fixed period. In the study, 200 mg/kg body weight (BW)/day (d) of TFE was given to mice for 14 weeks. The results showed that the levels of hepatic superoxide dismutase and reduced glutathione were increased but the formation of malondialdehyde was reduced, compared to the normal control (NC) group. Meanwhile, administration of TFE contributed to the prior number of colonic goblet cells (1,505 ± 124 vs. 1,162 ± 112, per mm2) and enhancement of colonic messenger RNA expression of mucin 2 and Claudin5. Additionally, TFE intervention modulated the composition and metabolic pathways of gut microbiota with an important role in dietary metabolism. Representatively, the relative abundance of genera Bacteroides, Prevotella, and Lachnospiracea_incertae_sedis, and the levels of short-chain fatty acids (SCFAs) and immunoglobulin A were increased. Taken together, long-term intake of TFE could promote hepatic antioxidant and modulate gut ecological status. These results could provide a reference for the development of TFE as a functional beverage.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
长期摄入茶(Camellia sinensis L.)花提取物体内肝脏抗氧化和肠道生态调节特性
茶花提取物(Camellia sinensis L.)是一种新型茶饮料。本研究的目的是探讨在摄入TFE一段时间后可能的功能。在实验中,小鼠连续14周给予200 mg/kg体重(BW)/天的TFE。结果表明,与正常对照组(NC)相比,肝脏超氧化物歧化酶和还原性谷胱甘肽水平升高,丙二醛的形成减少。同时,TFE对结肠杯状细胞(1,505±124 / mm2 vs 1,162±112 / mm2)的数量和mucin 2和Claudin5的结肠信使RNA表达均有促进作用。此外,TFE干预调节肠道微生物群的组成和代谢途径,在膳食代谢中起重要作用。具有代表性的是拟杆菌属(Bacteroides)、普雷沃氏菌属(Prevotella)和毛螺杆菌属(Lachnospiracea_incertae_sedis)的相对丰度以及短链脂肪酸(SCFAs)和免疫球蛋白A的水平升高。综上所述,长期摄入TFE可促进肝脏抗氧化,调节肠道生态状态。研究结果可为TFE功能性饮料的开发提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
A beetroot-based beverage produced by adding Lacticaseibacillus paracasei: an optimization study Safety evaluation of genetically modified crops Effect of pullulan active packaging, incorporated with silver nanoparticles, on cholesterol oxidation product concentrations in boiler meat during storage Sustainable rural economy and food security: An integrated approach to the circular agricultural model Mechanistic insight into ochratoxin A adsorption onto the cell wall of Lacticaseibacillus rhamnosus Bm01 and its impact on grape juice quality
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1