A. Dawidar, M. Abou-Elzahab, M. Berghot, K. H. AI-Maah
{"title":"Photooxygenation of β-sitosterol and stigmasterol and DNA-damaging properties of their hydroperoxide products","authors":"A. Dawidar, M. Abou-Elzahab, M. Berghot, K. H. AI-Maah","doi":"10.7019/CPJ.200212.0471","DOIUrl":null,"url":null,"abstract":"The phytosterol β-sitosterol (1), its acetate derivative (3) and stigmasterol (2) were photo-oxygenated using tetraphenyl porphorin (TPP) or rose Bengal (RB) and sensitizer in different solvents to give hydroperoxides 4,8 and dihydroperoxide 7, respectively. Structures 4,8 and 7 were elucidated on the basis of spectral data from their 1H NMR, MS and IR spectra. Product 7 produced moderate DNA degradation, but 4 did not.","PeriodicalId":22409,"journal":{"name":"The Chinese Pharmaceutical Journal","volume":"34 1","pages":"471-476"},"PeriodicalIF":0.0000,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Chinese Pharmaceutical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7019/CPJ.200212.0471","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The phytosterol β-sitosterol (1), its acetate derivative (3) and stigmasterol (2) were photo-oxygenated using tetraphenyl porphorin (TPP) or rose Bengal (RB) and sensitizer in different solvents to give hydroperoxides 4,8 and dihydroperoxide 7, respectively. Structures 4,8 and 7 were elucidated on the basis of spectral data from their 1H NMR, MS and IR spectra. Product 7 produced moderate DNA degradation, but 4 did not.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
