Impact of feeding flaxseed oil on delaying the development of osteoporosis in ovariectomised diabetic rats

International Journal of Food Safety, Nutrition and Public Health Pub Date : 2009-11-19 DOI:10.1504/IJFSNPH.2009.029284

M. El-Wassef, M. Anwar, M. Harvi, M.M. Abd El Moneim, G.S. EL Saeed, S.I. Salem, H. Wafay

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Abstract

This work is aimed to study the effect of diabetes on bone health and to evaluate the impact of feeding flaxseed oil on delaying osteoporosis. About 70 female albino rats were included; 30 were ovariectomised (ovx). Experimental diabetes was induced. Rats were classified in groups as control, sham, diabetic, diabetic received flaxseed oil in the diet, ovx, ovx-diabetic and ovx-diabetic received flaxseed oil in the diet. After two months, urine and blood samples were collected. Serum IGF-1 and osteocalcin were increased in ovx and diabetic ovx groups; their lowest levels were detected in the diabetic group. Upon adding flaxseed oil, their mean values were normalised. Urinary deoxypyridinoline was increased in diabetic group; the level was decreased as rats received flaxseed oil. Bone mineral density and content in diabetic group were reduced and normalised after receiving flaxseed oil. So, diabetes has more pronounced effect on bone health than ovariectomy, and flaxseed oil has beneficial effect on the prevention of osteoporosis.

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饲喂亚麻籽油对延缓去卵巢糖尿病大鼠骨质疏松发生的影响

本研究旨在研究糖尿病对骨健康的影响，并评价饲喂亚麻籽油对延缓骨质疏松症的影响。约70只雌性白化大鼠;30例卵巢切除。诱导实验性糖尿病。将大鼠分为对照组、假手术组、糖尿病组、糖尿病组在饲料中添加亚麻籽油，ovx组、ovx-糖尿病组和ovx-糖尿病组在饲料中添加亚麻籽油。两个月后，收集尿液和血液样本。ovx组和糖尿病ovx组血清IGF-1和骨钙素升高;在糖尿病组检测到最低水平。加入亚麻籽油后，将其平均值归一化。糖尿病组尿脱氧吡啶增多;大鼠服用亚麻籽油后，该水平降低。糖尿病组服用亚麻籽油后，骨密度和骨密度均降低并恢复正常。因此，糖尿病对骨骼健康的影响比卵巢切除术更明显，而亚麻籽油对预防骨质疏松症有有益作用。

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International Journal of Food Safety, Nutrition and Public Health

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