The role of gum Arabic as an anti-inflammatory, antioxidant, and immune modulator in the development of COVID-19: A review

Functional Food Science Pub Date : 2022-10-31 DOI:10.31989/ffs.v2i10.1019

Rasha Babiker, L. Kaddam, ABDALBASIT ADAM MARIOD

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Abstract

Background: Down-regulation of the lung inflammatory response seems to preserve pulmonary functions and improve survival in COVID-19. The key factor in overcoming the cytokine storm caused by COVID-19 by immunomodulation, rather than immunosuppression. Identifying the right mechanism to manipulate the immune regulatory networks in the lung—with minimal side effects—represents one of the many challenges in the treatment of COVID-19 disease. Immunomodulatory, anti-inflammatory, antioxidant, and gut-regulatory activities are the most significant properties of prebiotics. Therefore, it could be beneficial to consider them as an adjuvant dietary intervention among COVID-19 patients. Understanding the exact mechanism of prebiotic defense against infection and regulation of immune processes involved in COVID-19 are crucial for the development of novel therapeutic agents. Several studies considered Gum Arabic (GA) as a potent prebiotic with cytoprotective properties. This review aims to discuss and display the possibility of utilizing the beneficial effects of GA to modulate COVID-19 pathogenesis.Keywords: COVID-19, Gum Arabic, Immunomodulation, dietary intervention, Gut microbiota, Anti-inflammatory, Antioxidant

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阿拉伯胶作为抗炎、抗氧化和免疫调节剂在COVID-19发展中的作用:综述

背景:下调肺部炎症反应似乎可以保护COVID-19患者的肺功能并提高生存率。克服新冠病毒引起的细胞因子风暴的关键因素是免疫调节，而不是免疫抑制。确定在最小副作用的情况下操纵肺部免疫调节网络的正确机制，是治疗COVID-19疾病的众多挑战之一。免疫调节、抗炎、抗氧化和肠道调节活性是益生元最重要的特性。因此，将其作为COVID-19患者的辅助饮食干预可能是有益的。了解益生元抗感染的确切机制和COVID-19免疫过程的调控对于开发新型治疗剂至关重要。一些研究认为阿拉伯树胶(GA)是一种有效的具有细胞保护特性的益生元。本文旨在讨论和展示利用GA有益作用调节COVID-19发病机制的可能性。关键词:COVID-19，阿拉伯胶，免疫调节，饮食干预，肠道菌群，抗炎，抗氧化

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Functional Food Science

CiteScore

3.20

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