Epidemiology of severe acute respiratory syndrome-related coronavirus 2 antibodies in healthy blood donors and their follow-up.

IF 0.3 3区哲学 Q3 HISTORY & PHILOSOPHY OF SCIENCE Ambix Pub Date : 2023-07-01 Epub Date: 2022-09-28 DOI:10.4103/ajts.ajts_9_22

Rahul Chaurasia, Gopal Kumar Patidar, Hem Chandra Pandey, Suganya Palanisamy, Vidushi Gupta, Sapna Chopra, Poonam Coshic

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Abstract

Background: Asymptomatic/presymptomatic COVID-19 affected individuals who may appear healthy during blood donor screening can donate blood despite being infective. Most blood donors in India are relatives/friends/acquaintances of patients, who under peer pressure overlook the donor selection process, which can significantly impact the transfusion safety.

Aims: The prevalence of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) antibodies among blood donors was assessed, along with the possible transmissibility of SARS-CoV-2 virus in transfusion recipients of blood components prepared from sero-reactive blood donors.

Settings and design: A prospective cross-sectional study was conducted among eligible blood donors from November-2020 to April 2021.

Methods: 1500 blood donors were tested for SARS-CoV-2 IgG antibodies. Sero-reactive donors were followed-up telephonically to inquire about risk factors prior to donation or appearance of COVID-19 related symptoms postdonation. Patients transfused with blood components from seroreactive donors were also followed up for posttransfusion symptoms suggestive for COVID-19. Descriptive analysis was done for the donor and patient follow-up data.

Results: A total of 452 (30.1%) donor were reactive, with median S/CO ratio of 2.8 (interquartile range 1.5-5.5). Risk factors such as travel, contact, or quarantine were significantly higher among reactive donors. History of diabetes and/or hypertension was associated with seroreactivity. Total 516 patients were transfused with blood components from these seroreactive donors. Three patients developed fever after transfusion, one of which was found to be PCR positive after 4 days of transfusion.

Conclusion: Sero-reactivity rate among blood donors was lower than the general population. Optimum blood donor screening strategies can help decrease the possibility of blood collection from infected blood donors.

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健康献血者严重急性呼吸系统综合征相关冠状病毒 2 抗体的流行病学及其随访。

背景：在献血者筛选过程中，无症状/无症状的 COVID-19 感染者可能看起来很健康，尽管他们是感染者，也可以献血。目的：评估献血者中严重急性呼吸系统综合征相关冠状病毒 2（SARS-CoV-2）抗体的流行情况，以及 SARS-CoV-2 病毒在血清反应献血者制备的血液成分输血受体中的可能传播性：方法：对 1500 名献血者进行了 SARS-CoV-2 IgG 抗体检测。对血清反应性献血者进行电话随访，询问献血前的风险因素或献血后出现 COVID-19 相关症状的情况。对输注了血清反应性献血者血液成分的患者也进行了随访，以了解输血后是否出现了提示 COVID-19 的症状。对献血者和患者的随访数据进行了描述性分析：结果：共有 452 名（30.1%）献血者对 COVID-19 有反应，S/CO 比率中位数为 2.8（四分位数间距为 1.5-5.5）。在反应性供体中，旅行、接触或检疫等风险因素明显较高。糖尿病和/或高血压病史与血清反应性有关。共有 516 名患者输注了这些血清反应性献血者的血液成分。三名患者在输血后出现发热，其中一名患者在输血 4 天后发现 PCR 阳性：结论：献血者的血清反应率低于普通人群。结论：献血者的血清反应率低于普通人群。最佳的献血者筛查策略有助于降低从受感染献血者处采血的可能性。

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来源期刊

Ambix HISTORY & PHILOSOPHY OF SCIENCE-

CiteScore

0.80

自引率

60.00%

发文量

审稿时长

3 months

期刊介绍： Ambix is an internationally recognised, peer-reviewed quarterly journal devoted to publishing high-quality, original research and book reviews in the intellectual, social and cultural history of alchemy and chemistry. It publishes studies, discussions, and primary sources relevant to the historical experience of all areas related to alchemy and chemistry covering all periods (ancient to modern) and geographical regions. Ambix publishes individual papers, focused thematic sections and larger special issues (either single or double and usually guest-edited). Topics covered by Ambix include, but are not limited to, interactions between alchemy and chemistry and other disciplines; chemical medicine and pharmacy; molecular sciences; practices allied to material, instrumental, institutional and visual cultures; environmental chemistry; the chemical industry; the appearance of alchemy and chemistry within popular culture; biographical and historiographical studies; and the study of issues related to gender, race, and colonial experience within the context of chemistry.