{"title":"ANTIBIOTIC RESISTANCE: A FRIGHTENING HEALTH DILEMMA","authors":"R. Tiwari, K. Dhama","doi":"10.3844/AJPTSP.2014.174.176","DOIUrl":null,"url":null,"abstract":"The discovery of antibiotics, being the wonderful amiable pillars of chemotherapy, was a revolutioniz ed turning point in human history. With the discovery of antibiotic drug Penicillin in 1928, Sir Alexander Flemming explored the role of microbial products in counteracting the pathogenic effects of microorgani sms. Before 1940, antibiotics were magical drugs used as growth promoters, during the processing, storage an d transportation of food products to check secondary contaminations and for the treatment of various bac terial ailments (Byarugaba, 2004). However, very frequent, inappropriate and irrational use of antibiotics aga inst various microorganisms had a continuous survival pressure as a warning to their life and this pressu re forced them to express various resistance genes in equilibrium with environment to support the rise of antibiotic resistance to counteract antimicrobial approaches and to develop antibiotic resistance, in deed (Soulsby, 2005; Zhang et al ., 2006).","PeriodicalId":7769,"journal":{"name":"American Journal of Pharmacology and Toxicology","volume":"51 1","pages":"174-176"},"PeriodicalIF":0.0000,"publicationDate":"2014-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Pharmacology and Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3844/AJPTSP.2014.174.176","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
The discovery of antibiotics, being the wonderful amiable pillars of chemotherapy, was a revolutioniz ed turning point in human history. With the discovery of antibiotic drug Penicillin in 1928, Sir Alexander Flemming explored the role of microbial products in counteracting the pathogenic effects of microorgani sms. Before 1940, antibiotics were magical drugs used as growth promoters, during the processing, storage an d transportation of food products to check secondary contaminations and for the treatment of various bac terial ailments (Byarugaba, 2004). However, very frequent, inappropriate and irrational use of antibiotics aga inst various microorganisms had a continuous survival pressure as a warning to their life and this pressu re forced them to express various resistance genes in equilibrium with environment to support the rise of antibiotic resistance to counteract antimicrobial approaches and to develop antibiotic resistance, in deed (Soulsby, 2005; Zhang et al ., 2006).
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