A Case of Low Phosphorus Osteomalacia in a Young Woman

Abstract

Hypophosphorous osteomalacia (HO) is a rare metabolic disease. Due to hypophosphatemia and insufficient production of active vitamin D, the bone matrix can not be mineralized normally. Its clinical symptoms are atypical. It is generally manifested in bone pain and muscle weakness in different parts. With the progress of the disease, it is very easy to have osteoporosis, pathological fracture, bone deformity and damage to the function of other organs of the whole body. The etiology can be divided into primary and secondary according to the pathogenesis [1]. The primary is often caused by genetic factors, which can be divided into X-linked dominant low phosphorus osteomalacia (XLH) and autosomal dominant low phosphorus osteomalacia (ADHR). The secondary cause can be low phosphorus osteomalacia (TIO) caused by exposure to some drugs or heavy metals and tumors. This disease is rare in clinic, so clinicians have insufficient understanding of the disease and are prone to missed diagnosis or misdiagnosis. This paper reports a case of adult female with low phosphorus osteomalacia. The diagnosis, treatment and treatment are analyzed and discussed in order to provide reference for clinic.