{"title":"The Effects of Epigallocatechin-3-gallate on Adipocyte Glucose Transport and Differentiation, and Aberrant Lipid Metabolism-related Genes Expression","authors":"Hyuck Choi, K. Myung","doi":"10.29335/tals.2015.51.25","DOIUrl":null,"url":null,"abstract":"Background: Green tea catechins have been shown to promote loss of body fat and to inhibit growth of many cancer cell types by inducing apoptosis. Objective: The objective was to determine if epigallocatechin-3-gallate (EGCG) has ability to reduce differentiation in 3T3-L1 adipocytes and alter expression of aberrant lipid metabolism-related genes in HepG2 hepatocytes. Results: EGCG attenuated differentiation related gene expressions of adipocytes likely due to retarding glucose uptake in 3T3-L1 cells. EGCG decreased the concentration of cholesterol in HepG2 cell, resulting in the similar degree of suppression in apoB 100, and of enhancement in LDL receptor and HMG-CoA reductase mRNA levels. Conclusion: These results demonstrated that EGCG can act directly to inhibit differentiation of 3T3-L1 adipocytes and reduce abnormality in lipid metabolism-related genes in HepG2 hepatocytes, thus, could be a potent adjuvant in the treatment of obesity and metabolism","PeriodicalId":14931,"journal":{"name":"Journal of Agricultural Science and Technology","volume":"83 1","pages":"25-32"},"PeriodicalIF":1.2000,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Agricultural Science and Technology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.29335/tals.2015.51.25","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Green tea catechins have been shown to promote loss of body fat and to inhibit growth of many cancer cell types by inducing apoptosis. Objective: The objective was to determine if epigallocatechin-3-gallate (EGCG) has ability to reduce differentiation in 3T3-L1 adipocytes and alter expression of aberrant lipid metabolism-related genes in HepG2 hepatocytes. Results: EGCG attenuated differentiation related gene expressions of adipocytes likely due to retarding glucose uptake in 3T3-L1 cells. EGCG decreased the concentration of cholesterol in HepG2 cell, resulting in the similar degree of suppression in apoB 100, and of enhancement in LDL receptor and HMG-CoA reductase mRNA levels. Conclusion: These results demonstrated that EGCG can act directly to inhibit differentiation of 3T3-L1 adipocytes and reduce abnormality in lipid metabolism-related genes in HepG2 hepatocytes, thus, could be a potent adjuvant in the treatment of obesity and metabolism
期刊介绍：
Journal of Agricultural Science and Technology is one of the TMU Press journals that is published by the responsibility of its Editor-in-Chief and Editorial Board in the determined scopes.
Journal of Agricultural Science and Technology (JAST) is an international research journal published bimonthly for the purpose of advancing the scientific studies. The subjects covered by JAST include all aspects of agriculture and natural resources (see Areas Covered). The journal will consider submissions from all over the world, on research works not being published or submitted for publication towards publication as full paper, review article and research note. The Papers are published in English with an extra abstract in Persian.
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