STRATEGIES FOR MANAGEMENT OF ALZHEIMER’S DISEASE: A REVIEW

I. Sharma, Ankita Kumar
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引用次数: 2

Abstract

Alzheimer’s is the most widely recognized reason for dementia discovered by Alois Alzheimer’s in 1906. Severity of Alzheimer’s disease is increments with age and mostly after 65 years. It is a progressive neurodegenerative disease that damage memory and intellectual capacities. It affects 34 million people worldwide and as time goes, the pervasiveness of Alzheimer’s disease continues to increase and as indicated by WHO it can reaches to 95 million by 2050. Manifestation of Alzheimer’s incorporates cognitive decline that changes day by day way of life, trouble in finishing everyday errands, disarray with time or spot, misguide thinking. Most preferred drugs used for Alzheimer’s are cholinesterase inhibitors like Donepezil, rivastigmine, Galantamine, Tacrine, NMDA receptor antagonist like memantine. The purpose of this review article is to provide a brief introduction, potential causes, symptoms and mechanism of action of Alzheimer’s disease. This review article likewise accentuation on utilization of therapeutic plants and isolated compounds for preventing and reducing the symptoms of Alzheimer’s disease.
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阿尔茨海默病的治疗策略综述
阿尔茨海默氏症是1906年由阿洛伊斯·阿尔茨海默氏症发现的最被广泛认可的痴呆症原因。阿尔茨海默病的严重程度随着年龄的增长而增加,尤其是在65岁以后。它是一种进行性神经退行性疾病,会损害记忆和智力。它影响着全世界3400万人,随着时间的推移,阿尔茨海默病的普遍性继续增加,据世卫组织指出,到2050年可能达到9500万人。阿尔茨海默氏症的表现包括认知能力下降,改变日常生活方式,难以完成日常事务,时间或地点混乱,思维错误。阿尔茨海默氏症的首选药物是胆碱酯酶抑制剂,如多奈哌齐,利瓦斯汀,加兰他明,他克林,NMDA受体拮抗剂,如美金刚。本文就阿尔茨海默病的发病原因、症状及作用机制作一综述。本文还着重介绍了治疗植物和分离化合物在预防和减轻阿尔茨海默病症状方面的应用。
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