{"title":"MicroRNAs: The jack of all trades","authors":"S. Rehman, G. Baldassarre, G. Calin, M. Nicoloso","doi":"10.3816/CLK.2009.N.003","DOIUrl":null,"url":null,"abstract":"Abstract Focusing on the pervasive role of microRNAs (miRNAs), we review the multiple steps of malignant transformation, outlining the common hallmarks of tumorigenesis: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis. For each of these traits, we provide examples of miRNA contribution to the acquisition of a malignant phenotype. Finally, through an overview of the remarkable ability of miRNAs to regulate entire pathwaysas a result of the multiplicity of their targets, we highlight the attractive potential of developing miRNAtargeted therapies, which should affect all the aspects of tumorigenesis.","PeriodicalId":100271,"journal":{"name":"Clinical Leukemia","volume":"99 1","pages":"20-32"},"PeriodicalIF":0.0000,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Leukemia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3816/CLK.2009.N.003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Abstract Focusing on the pervasive role of microRNAs (miRNAs), we review the multiple steps of malignant transformation, outlining the common hallmarks of tumorigenesis: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis. For each of these traits, we provide examples of miRNA contribution to the acquisition of a malignant phenotype. Finally, through an overview of the remarkable ability of miRNAs to regulate entire pathwaysas a result of the multiplicity of their targets, we highlight the attractive potential of developing miRNAtargeted therapies, which should affect all the aspects of tumorigenesis.
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