{"title":"Diet and lifestyle interventions on lipids: combination with genomics and metabolomics","authors":"Yan Zheng, L. Qi","doi":"10.2217/clp.14.30","DOIUrl":null,"url":null,"abstract":"Abstract Lipids have been closely related to risk of a variety of metabolic disorders such as cardiovascular disease and diabetes. Compelling evidence has shown that diet/lifestyle interventions may affect circulating lipid profile; research in genetics has associated more than 150 common variants with lipid traits. In recent years, emerging data from observational studies and randomized clinical trials have shown that dietary and lifestyle factors might interact with genetic factors in determining lipid levels. In addition, the emerging ‘omics’ research, especially lipidomics, owns potentials to provide comprehensive insights into the mechanisms underlying gene–diet/lifestyle interactions. Although many challenges exist, studies in these areas hold promise to inform future personalized diet and lifestyle interventions on improvement of lipids and mitigate the related disorders.","PeriodicalId":55252,"journal":{"name":"Clinical Lipidology","volume":"61 1","pages":"417 - 427"},"PeriodicalIF":0.0000,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Lipidology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/clp.14.30","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 7
Abstract
Abstract Lipids have been closely related to risk of a variety of metabolic disorders such as cardiovascular disease and diabetes. Compelling evidence has shown that diet/lifestyle interventions may affect circulating lipid profile; research in genetics has associated more than 150 common variants with lipid traits. In recent years, emerging data from observational studies and randomized clinical trials have shown that dietary and lifestyle factors might interact with genetic factors in determining lipid levels. In addition, the emerging ‘omics’ research, especially lipidomics, owns potentials to provide comprehensive insights into the mechanisms underlying gene–diet/lifestyle interactions. Although many challenges exist, studies in these areas hold promise to inform future personalized diet and lifestyle interventions on improvement of lipids and mitigate the related disorders.
期刊介绍：
The Journal of Clinical Lipidology is published to support the diverse array of medical professionals who work to reduce the incidence of morbidity and mortality from dyslipidemia and associated disorders of lipid metabolism. The Journal''s readership encompasses a broad cross-section of the medical community, including cardiologists, endocrinologists, and primary care physicians, as well as those involved in the treatment of such disorders as diabetes, hypertension, and obesity. The Journal also addresses allied health professionals who treat the patient base described above, such as pharmacists, nurse practitioners and dietitians. Because the scope of clinical lipidology is broad, the topics addressed by the Journal are equally diverse. Typical articles explore lipidology as it is practiced in the treatment setting, recent developments in pharmacological research, reports of treatment and trials, case studies, the impact of lifestyle modification, and similar academic material of interest to the practitioner. While preference is given to material of immediate practical concern, the science that underpins lipidology is forwarded by expert contributors so that evidence-based approaches to reducing cardiovascular and coronary heart disease can be made immediately available to our readers. Sections of the Journal will address pioneering studies and the clinicians who conduct them, case studies, ethical standards and conduct, professional guidance such as ATP and NCEP, editorial commentary, letters from readers, National Lipid Association (NLA) news and upcoming event information, as well as abstracts from the NLA annual scientific sessions and the scientific forums held by its chapters, when appropriate.
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