IDENTIFICATION OF EFFECTIVE GENES OF MULTIPLE CANCERS USING NEURAL NETWORK

Saeideh Fouladlou, Mehdi Rajabioun, Darya Bahojb Hashemian
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Abstract

Cancer is a major health concern that affects a significant number of people worldwide and can often result in fatalities. Therefore, there is a growing need to develop effective approaches for early diagnosis and classification of different types of cancer. Early detection of cancer is crucial for prompt and accurate treatment. Thus, researchers have been working to identify non-invasive and precise methods for the early diagnosis, monitoring, and control of cancer. Leukemia and prostate cancer are two of the most common types of cancer globally. Microarray data analysis has become a valuable tool for diagnosing and classifying different types of cancerous tissues. To improve the accuracy of diagnosis, hybrid algorithms and neural networks are being employed. This paper provides a review of different biomarkers for leukemia and prostate cancer and proposes a novel method for distinguishing between the two cancers. The proposed method includes appropriate gene selection, a new hybrid model, and differential analysis of microarray data to create a diagnostic tool. The results indicate that the proposed algorithm is highly accurate and efficient in selecting a small set of valuable genes to improve classification accuracy. In conclusion, the accurate diagnosis and classification of cancer are essential for timely and effective treatment. The proposed method can contribute to the development of a reliable diagnostic tool for leukemia and prostate cancer, and the application of microarray data and hybrid algorithms can be useful for diagnosing other types of cancer as well.
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利用神经网络识别多种癌症的有效基因
癌症是一个重大的健康问题,影响着全世界许多人,往往会导致死亡。因此,越来越需要开发有效的方法来早期诊断和分类不同类型的癌症。早期发现癌症对于及时准确的治疗至关重要。因此,研究人员一直在努力寻找非侵入性和精确的方法来早期诊断、监测和控制癌症。白血病和前列腺癌是全球最常见的两种癌症。微阵列数据分析已成为诊断和分类不同类型癌组织的有价值的工具。为了提高诊断的准确性,采用了混合算法和神经网络。本文综述了白血病和前列腺癌的不同生物标志物,并提出了一种区分两种癌症的新方法。提出的方法包括适当的基因选择,一个新的杂交模型,和微阵列数据的差异分析,以创建一个诊断工具。结果表明,该算法在选择小范围有价值的基因方面具有较高的准确性和效率,从而提高了分类精度。总之,癌症的准确诊断和分类对于及时有效的治疗至关重要。该方法可为白血病和前列腺癌的可靠诊断工具的发展做出贡献,并且微阵列数据和混合算法的应用也可用于诊断其他类型的癌症。
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来源期刊
Biomedical Engineering: Applications, Basis and Communications
Biomedical Engineering: Applications, Basis and Communications Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.50
自引率
11.10%
发文量
36
审稿时长
4 months
期刊介绍: Biomedical Engineering: Applications, Basis and Communications is an international, interdisciplinary journal aiming at publishing up-to-date contributions on original clinical and basic research in the biomedical engineering. Research of biomedical engineering has grown tremendously in the past few decades. Meanwhile, several outstanding journals in the field have emerged, with different emphases and objectives. We hope this journal will serve as a new forum for both scientists and clinicians to share their ideas and the results of their studies. Biomedical Engineering: Applications, Basis and Communications explores all facets of biomedical engineering, with emphasis on both the clinical and scientific aspects of the study. It covers the fields of bioelectronics, biomaterials, biomechanics, bioinformatics, nano-biological sciences and clinical engineering. The journal fulfils this aim by publishing regular research / clinical articles, short communications, technical notes and review papers. Papers from both basic research and clinical investigations will be considered.
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