Different Methods of COVID-19 Detection

Abstract

Objective: Explore the performance of different test methods in detecting COVID-19 antibodies and antigens. Methods: Compare the results of different test methods on samples from novel coronavirus pneumonia patients, and randomly select some of the confirmed samples after gradient dilution to detect the sensitivity of the test products. The sample used for rapid detection of COVID-19 antigen was nasal swab. Three kinds of sample used in the detection of novel coronavirus antibodies were venipuncture/ fingerstick whole blood, serum and plasma. Results: The detection rate of covid-19 antibody increased with the increase of the onset time of patients, while the detection rate of antigen decreased gradually, which was in line with the nature of antigen and antibody in the human body. Conclusion: In view of the advantages of antibody and antigen detection, such as convenient and sample collection, high throughput, low workload, high reproducibility and low cost, we hope to lay a scientific foundation for the horizontal comparison of the data of products (Abbott, Roche, Healgen, AllTest, Citest, Siemens, Lepu, Wondfo) obtained in the research and practical application of epidemic prevention and control of COVID-19.