{"title":"Silybin-based herbal nanocarriers: an advancement in anticancer therapy","authors":"Meghanath B. Shete, A. S. Deshpande, P. Shende","doi":"10.1080/10667857.2022.2081286","DOIUrl":null,"url":null,"abstract":"ABSTRACT Silybin is a key bioactive component of silymarin that display health-promoting actions in many chronic diseases. However, its clinical applicability is curtailed by its inherent issues like low aqueous solubility, poor bioavailability, high metabolism, fast elimination, and poor penetration in intestinal epithelial cells. In this context, nanotechnology plays a crucial role to address several issues of the broad range of bioactives. In this review, the authors have discussed the anticancer mechanism of silybin and its synergistic combinations. Further, it summarizes the emerging nanocarriers used to deliver silybin alone or in combination like lipid-based, polymeric micelles, polymeric nanoparticles, carbon nanotubes, gold nanoparticles, nanoemulsion, nanosuspension, and hydrogel. Besides, it presents the repercussions of nano-silybin and the present scenario of clinical studies in the field of cancer. The application of nanotechnology brings the opportunity for silybin to be used as an alternative for effective therapy in cancer management in near future. ABSTRACT","PeriodicalId":18270,"journal":{"name":"Materials Technology","volume":"51 3 1","pages":"2832 - 2852"},"PeriodicalIF":2.9000,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Technology","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1080/10667857.2022.2081286","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 2
Abstract
ABSTRACT Silybin is a key bioactive component of silymarin that display health-promoting actions in many chronic diseases. However, its clinical applicability is curtailed by its inherent issues like low aqueous solubility, poor bioavailability, high metabolism, fast elimination, and poor penetration in intestinal epithelial cells. In this context, nanotechnology plays a crucial role to address several issues of the broad range of bioactives. In this review, the authors have discussed the anticancer mechanism of silybin and its synergistic combinations. Further, it summarizes the emerging nanocarriers used to deliver silybin alone or in combination like lipid-based, polymeric micelles, polymeric nanoparticles, carbon nanotubes, gold nanoparticles, nanoemulsion, nanosuspension, and hydrogel. Besides, it presents the repercussions of nano-silybin and the present scenario of clinical studies in the field of cancer. The application of nanotechnology brings the opportunity for silybin to be used as an alternative for effective therapy in cancer management in near future. ABSTRACT
期刊介绍：
Materials Technology: Advanced Performance Materials provides an international medium for the communication of progress in the field of functional materials (advanced materials in which composition, structure and surface are functionalised to confer specific, applications-oriented properties). The focus is on materials for biomedical, electronic, photonic and energy applications. Contributions should address the physical, chemical, or engineering sciences that underpin the design and application of these materials. The scientific and engineering aspects may include processing and structural characterisation from the micro- to nanoscale to achieve specific functionality.
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