Study of Pentoxifylline Chemical Stability from Modified Release Tablets with Hydrophilic Mould

Abstract

Thermal and chemical stability of pentoxifylline from modified release tablets were studied. This experimental study observed the influence of temperature and humidity on the stability of pentoxifylline from the proposed formulations. The paper describes the HPLC determination of pentoxifylline from new controlled release tablets with hydrophilic matrix (HPMC, HPC, HEC). A C18 column with a mobile phase containing water : acetonitrile 70:30 (V/V) and UV detection at 280 nm was used. The "in vitro" dissolution test was carried out regarding the officinal stipulations of USP; the machine nr.2 was used (with paddles); as dissolution environment 1000 ml water, a constant temperature of 37 plusmn 0.5degC was kept. In all experiences, the rotation speed was 50 rpm. The studied tablets were kept in the stability chamber at a temperature of 40 plusmn 2degC and a relative humidity of 75 plusmn 5%. At different time intervals (a month, three months, six months), samples were prelevated to accomplish the dissolution test and the quantitative determination of pentoxifylline. From the evaluation of the experimental results, we observed the stability of pentoxifylline from all the prepared tablets.