The Prognostic Value of Lymphocyte-to-Monocyte Ratio and Nutritional Index for Ovarian Cancer Patients with Normal CA125 Level

Abstract

this index was originally examined. In this study, a low NI was seen as a poor survival predictor. Abstract Background: Ovarian Cancer (OC) cases with low CA-125 concentration during routine physical examination testing are troublesome and raise false negative findings ratio. The aim of this analysis was to determine whether the Lymphocyte-To-Monocyte Ratio (LMR) and the Nutritional Index (NI) of OC patients with normal CA-125 levels had a predictive role. Methods: This retrospective study enrolled a total of 102 OC-diagnosed patients who underwent primary cytoreductive surgery and adjuvant platinum-based chemotherapy from 2010 to 2019. Using Receiver Operating Characteristic Curves (ROC) for survival analysis, optimum cut-off values for NI and LMR were calculated. The Kaplan-Meier (KM) curve and Cox regression determined the prognostic value for Overall Survival (OS) and Progression-Free Survival (PFS). Results: The results showed that the optimal cutoff values were 47.5 and 4.25, respectively, for NI and LMR. NI was shown to be significantly correlated with FIGO stage, Grade, the involvement of malignant ascites, and platinum response, and LMR with FIGO stage, lymph node metastasis, malignant ascites, and platinum response when the population was separated using optimized cut-off. The 5-year OS and PFS were greatly enhanced by a high NI ( ≧ 47.5). A low LMR (<4.25) was associated significantly with poor 5-year PFS and OS. Both NI and LMR were independent prognosticators for the 5-year OS in multivariate analysis. Conclusions: In CA125-normal ovarian cancer cases, elevated NI and LMR are positive prognosticators.