The outcome of Minibiobank under adverse conditions in Iraq

Mohemid Maddallah Mohammed AlJebouri
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引用次数: 5

Abstract

T University of Arizona Biorepository is responsible for collecting, storing, tracking, processing, and distributing human tissue, blood, and other bio-specimens. The Biorepository’s mission is to provide high-quality, clinically annotated specimens to the research community at this and other institutions as well as to industry involved in biomedical research. Researchers can use the stored materials for future research studies to learn more about cancer, diabetes, and other health problems. The bank will provide a ready supply of samples, so researchers do not have to look for donors for each new study. The biorepository provides consistent collection, processing, banking and clinical correlative procedures and operates in conjunction with departments of Surgery, Ophthalmology, Pulmonology, Aging, Neurology, Neurosurgery, Biomedical Engineering, OB-GYN, Cardiology and others. Currently the bio-repository has in its possession 1.5 million patient samples obtained through Pathology. The bio-repository utilizes universal electronic consents providing annotated clinical data on each patient through an Honest Broker arrangement. All samples are linked to patient medical identifiers allowing for access to the electronic health record now and at all times in the future in a deidentified fashion. Fresh frozen paraffin blocks, blood, plasma, sera, urine and other biological fluids; as well as biopsies and other tissues/bio-samples are stored. In addition, DNA/RNA/proteins are also banked for all samples. Significantly, we have now developed methodology allowing for genomic and phenotypic sample characterization for approx. $2/patient sample. As all samples are stored according to industry best practices, in temperature-controlled, monitored, and alarmed environments (in LN2 or other freezers as appropriate) to maximize resource integrity utilizing cGTP practices whenever possible, the biorepository also serves as a source of cells and tissues for projects involving translational and regenerative medicine. To facilitate investigator interactions the biorepository utilizes Tissue Metrix2 as the central database for information on all banked bio-samples. The software has a web-based front-end with an Oracle database which permits access from web browsers across multiple platforms. It employs role based security to permit control over user access to information stored in the database. The i2b2 open source exploration tool is used as a storefront for investigator sample requests in a text based format.
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微型生物银行在伊拉克不利条件下的结果
亚利桑那大学生物储存库负责收集、储存、跟踪、处理和分发人体组织、血液和其他生物标本。生物储存库的使命是为本院和其他机构的研究界以及涉及生物医学研究的行业提供高质量的临床注释标本。研究人员可以将储存的材料用于未来的研究,以了解更多关于癌症、糖尿病和其他健康问题的信息。该银行将提供现成的样本供应,因此研究人员不必为每项新研究寻找捐赠者。生物储存库提供一致的收集、处理、存储和临床相关程序,并与外科、眼科、肺科、老龄化、神经病学、神经外科、生物医学工程、妇产科、心脏病学等部门合作。目前,生物信息库拥有通过病理学获得的150万例患者样本。生物资源库利用通用电子同意,通过诚实经纪人安排为每位患者提供注释的临床数据。所有样本都与患者医疗标识符相关联,允许现在和将来任何时候以不识别的方式访问电子健康记录。新鲜冷冻石蜡块、血液、血浆、血清、尿液等生物体液;以及活组织检查和其他组织/生物样本被储存。此外,所有样品的DNA/RNA/蛋白质也被储存起来。值得注意的是,我们现在已经开发了一种方法,允许基因组和表型样品表征大约。2美元/患者样本。由于所有样品都按照行业最佳实践保存,在温度控制、监测和警报环境中(在LN2或其他适当的冷冻室中),尽可能利用cGTP实践最大限度地提高资源完整性,生物库还可作为涉及转化和再生医学项目的细胞和组织的来源。为了方便研究者的互动,生物库利用组织Metrix2作为所有生物样本信息的中心数据库。该软件有一个基于web的前端,使用Oracle数据库,允许跨多个平台的web浏览器访问。它采用基于角色的安全性来控制用户对存储在数据库中的信息的访问。i2b2开源探索工具被用作基于文本格式的调查员样本请求的店面。
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