Ichthyosis as a paraneoplastic syndrome and atypical variant of mycosis fungoides: two cases report

Abstract

Acquired ichthyosis is a known paraneoplastic sign of lymphoproliferative malignancies, but ichthyosiform eruption can also constitute a rare atypical variant of mycosis fungoides. Ichthyosiform mycosis fungoides differs from acquired ichthyosis associated with mycosis fungoides in histopathology. Histological pictures of paraneoplastic ichthyosis usually do not show any aspect related to malignancy in the skin. In both cases thinning of the granular layer and decrease of filaggrin in that layer are observed. We describe here 2 patients with mycosis fungoides, who were treat ed in the Department of Dermatology, the first one with ichthyosiform mycosis fungoides and the other one with acquired ichthyosis with coexisting mycosis fungoides.