The Association Of Body Mass Index And Prostatic Cancer Histopathological Grade

Abstract

Background: Obesity, a global public health concern, has been repeatedly linked to the development of different cancers in epidemiologic and basic research studies, Prostate cancer is the most frequently encountered solid tissue cancer in men. Gleason score of the prostate cancer is one of the most important parameter, which provides the most important data about biological behavior of the cancer and affect on the selection of the treatment and its outcomes. Therefore, accuracy of Gleason score, based on histopathological analysis of the biopsy material, has a critical importance Patients and Methods: A cross-sectional study with retrospective analytical elements, among prostate cancer patients who were diagnosed based on histopathology of prostate gland ,then classified accorrding to G.S (gleasson score) and body mass index. Aim of this study: To evaluate the association between high body mass index and Gleason grade of prostate cancer. Results: The results of this study showed that patients with high body mass index Significantly associated with high grade of prostate cancer, as ( 46.4% and 62.2% of overweight and obese patients respectively had high Gleason score above 7 while 12.5% of overweight and 8.1% of obese patients had low Gleason score and the p Value was (0.002). Conclusion: This study found that high body mass index associated with increase high grade of prostate cancer.