{"title":"Making New Ties","authors":"","doi":"10.1126/scisignal.1482002tw326","DOIUrl":null,"url":null,"abstract":"Neurons communicate with one another through specialized junctions called synapses that are so robust that they survive homogenization. Although several cell-surface receptor-ligand pairs have been proposed to participate in forming and maintaining synapses, one of the best families of candidates--the immunoglobulin-domain proteins--have only been found in invertebrates. Biederer et al. report that IGSF4 is a homophilic protein that can induce the formation of fully functional glutamatergic synapses when cotransfected into nonneural, vertebrate human embryonic kidney (HEK) cells along with glutamate receptors. T. Biederer, Y. Sara, M. Mozhayeva, D. Atasoy, X. Liu, E. T. Kavalali, T. C. Südhof, SynCAM, a synaptic adhesion molecule that drives synapse assembly, Science 297, 1525-1531 (2002). [Abstract] [Full Text]","PeriodicalId":21619,"journal":{"name":"Science's STKE","volume":"6 1","pages":"tw326 - tw326"},"PeriodicalIF":0.0000,"publicationDate":"2002-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science's STKE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1126/scisignal.1482002tw326","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Neurons communicate with one another through specialized junctions called synapses that are so robust that they survive homogenization. Although several cell-surface receptor-ligand pairs have been proposed to participate in forming and maintaining synapses, one of the best families of candidates--the immunoglobulin-domain proteins--have only been found in invertebrates. Biederer et al. report that IGSF4 is a homophilic protein that can induce the formation of fully functional glutamatergic synapses when cotransfected into nonneural, vertebrate human embryonic kidney (HEK) cells along with glutamate receptors. T. Biederer, Y. Sara, M. Mozhayeva, D. Atasoy, X. Liu, E. T. Kavalali, T. C. Südhof, SynCAM, a synaptic adhesion molecule that drives synapse assembly, Science 297, 1525-1531 (2002). [Abstract] [Full Text]
神经元通过称为突触的特殊连接相互交流，突触非常坚固，可以在同质化过程中存活下来。虽然已经提出了几种细胞表面受体配体对参与突触的形成和维持，但最好的候选家族之一-免疫球蛋白结构域蛋白-仅在无脊椎动物中被发现。Biederer等人报道，IGSF4是一种同源蛋白，当与谷氨酸受体一起共转染到非神经、脊椎动物人胚胎肾(HEK)细胞时，可以诱导形成全功能的谷氨酸能突触。T. Biederer, Y. Sara, M. Mozhayeva, D. Atasoy, X. Liu, E. T. Kavalali, T. C. s dhof, SynCAM:驱动突触组装的突触粘附分子，Science, 297, 1525-1531(2002)。【摘要】【全文】
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