Prevalence of anticonvulsant-induced vitamin D deficiency

E. Dontseva, P. Pilipenko, N. A. Shnayder, M. M. Petrova, R. Nasyrova
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引用次数: 1

Abstract

Background. Epilepsy is a common disease in children and adults, requiring long-term or lifelong use of antiepileptic drugs (AEDs) in 60% of cases. Enzyme-inducing and enzyme-inhibiting AEDs may have a negative effect on vitamin D metabolism. However, at present, standard treatment protocols for patients with epilepsy include no nutrients and vitamin-mineral vitamin D containing complexes.Objective: to analyze studies on the prevalence of vitamin D deficiency induced by AEDs intake in patients with epilepsy.Material and methods. The search for full-text publications in Russian and English was carried out in еLibrary, PubMed/ MEDLINE, ClinicalKey, Google Scholar databases, covering the last five years. The analysis included 9 domestic and 54 foreign epidemiological studies assessing prevalence of AED-induced vitamin D deficiency and, consequently, altered bone mineralization and osteomalacia/osteoporosis.Results. Both in children and adults, the prevalence of AED-induced vitamin D deficiency reaches 40% and even higher. The region of residence of patients with epilepsy does not significantly affect this indicator. Impaired bone mineralization is associated with AED-induced vitamin D deficiency and requires the inclusion of vitamin D in the protocols of disease-modifying epilepsy therapy in children and adults.Conclusion. The results of the review showed high relevance of the discussed interdisciplinary problem and need to introduce laboratory screening of vitamin D deficiency among pediatric and adult patients with epilepsy.
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抗惊厥药引起的维生素D缺乏的患病率
背景。癫痫是儿童和成人的常见病,60%的病例需要长期或终生使用抗癫痫药物(aed)。酶诱导和酶抑制AEDs可能对维生素D代谢有负面影响。然而,目前癫痫患者的标准治疗方案包括无营养素和含维生素-矿物质维生素D复合物。目的:分析癫痫患者服用抗癫痫药导致维生素D缺乏的情况。材料和方法。在数据库中检索了近5年的俄文和英文全文出版物,检索数据库包括:数据库数据库、PubMed/ MEDLINE数据库、ClinicalKey数据库、Google Scholar数据库。分析了9项国内流行病学研究和54项国外流行病学研究,评估了aed引起的维生素D缺乏症的患病率,并由此改变了骨矿化和骨软化症/骨质疏松症。在儿童和成人中,aed引起的维生素D缺乏症的患病率达到40%甚至更高。癫痫患者居住地区对该指标无显著影响。骨矿化受损与aed诱导的维生素D缺乏有关,需要在儿童和成人的疾病改善癫痫治疗方案中纳入维生素D。该综述的结果显示了所讨论的跨学科问题的高度相关性,并且需要在儿童和成人癫痫患者中引入维生素D缺乏症的实验室筛查。
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来源期刊
Epilepsy and Paroxysmal Conditions
Epilepsy and Paroxysmal Conditions Medicine-Neurology (clinical)
CiteScore
0.90
自引率
0.00%
发文量
31
审稿时长
8 weeks
期刊最新文献
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