Prevalence and Distribution of Human Papillomavirus Genotypes (1997-2019) and Their Association With Cervical Cancer and Precursor Lesions in Women From Southern Mexico.

IF 0.3 4区社会学 0 HUMANITIES, MULTIDISCIPLINARY Modernism/modernity Pub Date : 2022-01-01 DOI:10.1177/10732748221103331

Luz Del Carmen Alarcón-Romero, Jorge Organista-Nava, Yazmín Gómez-Gómez, Julio Ortiz-Ortiz, Daniel Hernández-Sotelo, Oscar Del Moral-Hernández, Miguel Angel Mendoza-Catalán, Ramón Antaño-Arias, Marco Antonio Leyva-Vázquez, Natividad Sales-Linares, Verónica Antonio-Véjar, Berenice Illades-Aguiar

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Abstract

Background: Cervical cancer (CC) is the fourth most common malignancy of the female genital tract. Human Papillomavirus (HPV) is the main cause of precancerous lesions and CC cases worldwide.

Objective: We assessed the prevalence and distribution of HPV types and their association with precancerous lesions and CC.

Methods: HPV genotypes were detected by 3 methods depending on the year of in which the sample was analyzed: MY09/11 RFLPs (1997 to 2010), GP5+/6+ primer systems (2005 to 2010) and INNO-LiPA HPV Genotyping Extra (2010 to 2019) in cervical samples (No-IL: 4445; LSIL: 2464; HSILs: 151 and CC: 253) from women from southern Mexico.

Results: The overall HPV prevalence was 54.17%, and hpv-16 was the most common genotype. In single infection, the high-risk HPV genotypes (group 1) were associated with squamous intraepitelial lesions (LSIL: HPV-39 (OR = 10.58, 95% CI 4.09-27.36, P < .001); HSIL: HPV-31 (OR = 14.76, 95% CI 6.56-33.20, P < .001); and CC: HPV-16 (OR = 25.01, 95% CI 18.83-33.21, P < .001). In multiple infections, the HPV genotypes (HPV-16 and HPV-18) were also associated with a high risk of lesions [LSIL: HPV-18 (OR = 3.45; 95% CI 1.36-8.91; P = .009); HSIL: HPV-18 (OR = 5.12; 95% CI 1.21-21.68; P = .026); and CC: HPV-16 (OR = 3.03; 95% CI 1.72-5.32; P < .001)] compared to single infection. In the analysis adjusted for age, giving birth, and cigarette smoking, a significant increase in the risk of LSIL, HSIL, and CC was maintained.

Conclusions: This study provides current data on the prevalence and distribution of HPV genotypes in women from southern Mexico, which could serve as a valuable reference to guide nationwide CC screening programs and provide scientific evidence that could be useful for vaccine development efforts. Likewise, it was identified that infection with carcinogenic HPV genotypes is an independent risk factor for LSIL, HSIL, and CC.

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墨西哥南部妇女中人类乳头瘤病毒基因型的流行和分布（1997-2019 年）及其与宫颈癌和前驱病变的关系。

背景：宫颈癌（CC）是女性生殖道第四大常见恶性肿瘤。人乳头瘤病毒（HPV）是导致全球癌前病变和宫颈癌病例的主要原因：我们评估了 HPV 类型的流行和分布情况，以及它们与癌前病变和 CC 的关联：墨西哥南部妇女宫颈样本（No-IL：4445；LSIL：2464；HSILs：151和CC：253）中的MY09/11 RFLPs（1997年至2010年）、GP5+/6+引物系统（2005年至2010年）和INNO-LiPA HPV Genotyping Extra（2010年至2019年）：结果：HPV 的总体感染率为 54.17%，hpv-16 是最常见的基因型。在单次感染中，高危 HPV 基因型（第 1 组）与鳞状表皮内病变相关（LSIL：HPV-39（OR = 10.58，95% CI 4.09-27.36，P < .001）；HSIL：HPV-31（OR = 14.76，95% CI 6.56-33.20，P < .001）；CC：HPV-16（OR = 25.01，95% CI 18.83-33.21，P < .001）。在多次感染中，与单次感染相比，HPV 基因型（HPV-16 和 HPV-18）也与高病变风险相关[LSIL：HPV-18（OR = 3.45；95% CI 1.36-8.91；P = .009）；HSIL：HPV-18（OR = 5.12；95% CI 1.21-21.68；P = .026）；CC：HPV-16（OR = 3.03；95% CI 1.72-5.32；P < .001）]。在对年龄、生育和吸烟进行调整后的分析中，LSIL、HSIL 和 CC 的风险仍显著增加：这项研究提供了墨西哥南部妇女中 HPV 基因型流行和分布的最新数据，可作为指导全国 CC 筛查计划的宝贵参考，并为疫苗开发工作提供有用的科学证据。同样，研究还发现，感染致癌 HPV 基因型是导致 LSIL、HSIL 和 CC 的独立风险因素。

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Modernism/modernity HUMANITIES, MULTIDISCIPLINARY-

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0.20

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期刊介绍： Concentrating on the period extending roughly from 1860 to the present, Modernism/Modernity focuses on the methodological, archival, and theoretical exigencies particular to modernist studies. It encourages an interdisciplinary approach linking music, architecture, the visual arts, literature, and social and intellectual history. The journal"s broad scope fosters dialogue between social scientists and humanists about the history of modernism and its relations tomodernization. Each issue features a section of thematic essays as well as book reviews and a list of books received. Modernism/Modernity is now the official journal of the Modernist Studies Association.

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