{"title":"Reversal of multidrug resistance by non-antitumor anthracycline analogs.","authors":"Makoto Inaba, Kyoko Nagashima, Yoshio Sakurai, Masaru Fukui, Yoshikazu Yanagi","doi":"10.20772/CANCERSCI1959.75.12_1049","DOIUrl":null,"url":null,"abstract":"It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"27 1","pages":"1049-52"},"PeriodicalIF":0.0000,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"28","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Philosophia (Ramat-Gan, Israel)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20772/CANCERSCI1959.75.12_1049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 28
Abstract
It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.
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