EFFECTIVENESS OF TARA DARA (Catharanthus roseus L.) BOILED WATER TOWARD UREUM LEVELS AND CREATININ RATS OF WISTAR GALUR WALL STRAPS

Abstract

Acute kidney failure is a disorder that occurs suddenly in the ability of the kidneys to infiltrate blood, which is characterized by increased levels of ureum and creatinine within a few days or weeks. This study aims to determine the effectiveness of the tread (Catharanthus roseus L.) on the levels of ureum and creatinine in male wistar strain models of acute kidney failure. The object of the study were 30 male Wistar strain rats aged 2-3 months with a weight of 180-200 grams per rat. The study was divided into three groups, namely the treatment group, positive control group, and negative control group. Each group consisted of 10 male rats. Tread leaves taken as much as 5.2 grams are boiled in 300 cc of water until the remaining 100 cc of boiled water. The treatment group and positive control group induced gentamicin 12 mg intra peritoneal / rat / day for the second 7 days. The treatment group was given boiled water for as much as 3.6 cc / day orally for 7 days. Giving a gentamicin injection to damage the kidneys. Data collection on urea and creatinine levels was calculated using the SPSS program version 24 One Way ANOVA test to compare creatinine urea levels. The results showed that there were significant differences in creatinine urea levels between the treatment group and the positive control group (p <0.05). This study concludes that the boiled water of the tread (Catharanthus roseus L.) is effective in reducing the level of ureum and creatinine of male rats in the Wistar strain model of acute kidney failure.