Hypoglycemic Action of Seed Kernel of Caesalpinia bonducella Fleming In Normal and Alloxan- Induced Diabetic Albino Rats

Abstract

The aim of the present study is to evaluate the hypoglycemic action of ethanolic extract of seed kernel of Caesalpinia bonducella Fleming on normal and alloxan-induced diabetic albino rats. The ethanolic extract (200mg/kg/d) was administered orally for two weeks to alloxan-induced diabetic rats. Blood glucose was estimated every week for two consecutive weeks along with body weight monitoring. For evaluation of mechanism of action of test drug, glycogen estimation was done in liver, heart and skeletal muscle and effect on adrenaline-induced hyperglycemia was seen. The test drug significantly (p<0.05) reduced the rise in blood glucose induced by alloxan. The test drug produced significant (p<0.05) increase in liver glycogen and also significantly (p<0.05) reduced adrenaline-induced hyperglycaemia. Significant (p<0.05) lowering of normal blood glucose was also found. Thus, the seed kernel of Caesalpinia bonducella has significant antidiabetic and hypoglycemic activity.