Bio-Engineering of Wounds by PRP Led Regeneration

C. Mahakalkar, S. Shrivastava, A. Gupta, S. Naik, Meghali N. Kaple, K. Chandanwale
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引用次数: 1

Abstract

Platelet rich plasma (PRP) therapy is one of the biological interventions in regenerative medicine with a sure success in clinical translations of wound healing. Platelet rich plasma is an autologous plasma fraction of peripheral blood and it’s the simplest intervention of regenerative medicine. It is rapidly extending to multiple clinical fields because of its easy use and biosafety which facilitates translation in humans. The biggest advantage over other therapies is it’s being autologous, no adverse events or reactions are encountered. The economic as well as social burden caused due to chronic and degenerative disease is well cared by this autologous therapy. The clinical applications have proven its efficacy and efficiency in healing all types of wounds. The microscopic and histopathological changes in the tissues after PRP therapy are described in this article. The changes in the tissues have evoked the transformation from fibrosis led healing to collagen led healing; a bioengineered mechanism of PRP led regeneration of wounds.
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PRP诱导伤口再生的生物工程研究
富血小板血浆(PRP)治疗是再生医学的生物干预手段之一,在伤口愈合的临床转化中取得了一定的成功。富血小板血浆是外周血的一种自体血浆,是再生医学中最简单的干预手段。由于其易于使用和生物安全性,便于在人体中转化,因此正在迅速扩展到多个临床领域。与其他疗法相比,最大的优势是它是自体的,没有不良事件或反应。由于慢性和退行性疾病引起的经济和社会负担很好地照顾到这种自体治疗。临床应用证明其对各类伤口的愈合效果良好。本文描述了PRP治疗后组织的显微和组织病理学变化。组织的变化引起了由纤维化主导的愈合向胶原主导的愈合的转变;PRP导致伤口再生的生物工程机制。
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