Photochemical transformations of 5-halogeno-4-thiouridines

G. Wenska, Katarzyna Taras-Goślińska, Katarzyna Lamparska-Kupsik, B. Skalski, M. Gdaniec, Z. Gdaniec
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引用次数: 4

Abstract

A series of 2′,3′,5′-tri-O-acetyl-5-halogeno-4-thiouridines, where halogen = Br, Cl, F, are synthesized and their photochemical transformations upon irradiation with near-UV light (λ > 300 nm) in aqueous acetonitrile solutions investigated. The main photochemical pathways in each case involve intermolecular additions leading to three main photoproducts with different relative distributions. The photoproducts are isolated and their structures determined based on MS, 1H and 13C NMR and UV spectral data.
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5-卤代-4-硫脲的光化学转化
合成了一系列卤素为Br、Cl、F的2′,3′,5′- 3 -乙酰基-5-卤代-4-硫脲类化合物,并研究了它们在近紫外光(λ > 300 nm)照射下在乙腈水溶液中的光化学转化。每种情况下的主要光化学途径都涉及分子间加成,导致三种具有不同相对分布的主要光产物。通过MS、1H、13C NMR和UV光谱对产物进行了分离和结构分析。
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