Zebularine-Resistant Human Cytidine Deaminase Mutants for Optimal Chemoprotection of Hematopoietic Stem Cells

Hongmei Ruan, M. Black
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引用次数: 2

Abstract

Acute myeloid leukemia (AML) is the most common type of acute leukemia. According to the National Cancer Institute, the new cases and deaths from AML in the United States in 2016 are estimated to be approximately 19,990 and 13,400, respectively, with a 5 year survival rate of only about 26.6% (http://seer.cancer.gov/statfacts/html/amyl. html). Thus, there is an urgent need to find more effective ways to improve the clinical treatment of AML.
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抗斑马碱人胞苷脱氨酶突变体对造血干细胞的最佳化学保护
急性髓性白血病(AML)是最常见的急性白血病类型。根据美国国家癌症研究所的数据,2016年美国AML的新病例和死亡人数估计分别约为19990例和13400例,5年生存率仅为26.6% (http://seer.cancer.gov/statfacts/html/amyl)。html)。因此,迫切需要寻找更有效的方法来改善AML的临床治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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