Susana Velasco-Lozano, F. López‐Gallego, J. C. Mateos-Díaz, E. Favela‐Torres
{"title":"Cross-linked enzyme aggregates (CLEA) in enzyme improvement – a review","authors":"Susana Velasco-Lozano, F. López‐Gallego, J. C. Mateos-Díaz, E. Favela‐Torres","doi":"10.1515/boca-2015-0012","DOIUrl":null,"url":null,"abstract":"Abstract Structural and functional catalytic characteristics of cross-linked enzyme aggregates (CLEA) are reviewed. Firstly, advantages of enzyme immobilization and existing types of immobilization are described. Then, a wide description of the factors that modify CLEA activity, selectivity and stability is presented. Nowadays CLEA offers an economic, simple and easy tool to reuse biocatalysts, improving their catalytic properties and stability. This immobilization methodology has been widely and satisfactorily tested with a great variety of enzymes and has demonstrated its potential as a future tool to optimize biocatalytic processes.","PeriodicalId":8747,"journal":{"name":"Biocatalysis","volume":"1 1","pages":"166 - 177"},"PeriodicalIF":0.0000,"publicationDate":"2016-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"93","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biocatalysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/boca-2015-0012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 93
Abstract
Abstract Structural and functional catalytic characteristics of cross-linked enzyme aggregates (CLEA) are reviewed. Firstly, advantages of enzyme immobilization and existing types of immobilization are described. Then, a wide description of the factors that modify CLEA activity, selectivity and stability is presented. Nowadays CLEA offers an economic, simple and easy tool to reuse biocatalysts, improving their catalytic properties and stability. This immobilization methodology has been widely and satisfactorily tested with a great variety of enzymes and has demonstrated its potential as a future tool to optimize biocatalytic processes.
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