Analysis of the frequency distribution of five single‐nucleotide polymorphisms of the MTRRgene in a Chinese pediatric population with acute lymphoblastic leukemia

Miao Li, Xiao-yan Kong, Shu‐Mei Wang
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引用次数: 1

Abstract

The objective of the present study was to examine the frequency distribution of five single‐nucleotide polymorphisms (SNPs; rs1801394 A>G, rs1532268 C>T, rs162036 A>G, rs10380 C>T, and rs9332 C>T) of the methionine synthase reductase (MTRR) gene, their effects on methotrexate (MTX) concentration, and the risk of relapse in a Chinese pediatric population with acute lymphoblastic leukemia (ALL).
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中国儿童急性淋巴细胞白血病患者mtrr基因5个单核苷酸多态性的频率分布分析
本研究的目的是检查五种单核苷酸多态性(snp)的频率分布;rs1801394 A>G、rs1532268 C>T、rs162036 A>G、rs10380 C>T、rs9332 C>T)对中国急性淋巴细胞白血病(ALL)患儿甲硫氨酸合成酶还原酶(MTRR)基因的表达及其对甲氨蝶呤(MTX)浓度和复发风险的影响。
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