An in vitro study of the origanum minutiflorum O. Schwarz & P. H. Davis and Coriandrum sativum L. essential oils as chronic tonsillitis therapeutics: antibacterial, antibiofilm, antioxidant, and cytotoxic activities

IF 2.2 3区农林科学 Q3 CHEMISTRY, APPLIED Journal of Essential Oil Research Pub Date : 2022-08-06 DOI:10.1080/10412905.2022.2107103

M. Kostić, Marija Ivanov, Tatjana Marković, Snežana Sanković Babić, L. Barros, R. Calhelha, M. Soković, A. Ćirić

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引用次数: 1

Abstract

ABSTRACT The chemical composition and biological activity of essential oils (EOs) from leaves of Origanum minutiflorum O. Schwarz & P.H.Davis, and seeds of Coriandrum sativum L. were investigated. Chemical analyses of EOs were performed and the major components were carvacrol (81.5%) and linalool (69.6%), respectively. The antimicrobial activity was assessed against several bacteria originating from the tonsillar tissue. Activities of EOs against Staphylococcus aureus biofilm were investigated, as well as the effect of the mixture of these EOs and antibiotics against the pathogen. The antioxidant activity of both EOs was determined by TBARS assay, and examined wild oregano EO showed better activity. Also, cytotoxicity of EOs was evaluated in vitro and both EOs showed potential to inhibit further proliferation of tumor cells. This study reported for the first time the effects of EOs on chronic tonsillitis causative pathogens, supporting their role as a natural bioactive therapeutic agent with possible antimicrobial applications.

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芫荽精油治疗慢性扁桃体炎的体外研究:抗菌、抗生物膜、抗氧化和细胞毒活性

摘要:研究了Origanum minutiflorum O. Schwarz和P.H.Davis叶片和芫荽(Coriandrum sativum L.)种子精油的化学成分和生物活性。对精油进行化学分析，主要成分为香芹酚(81.5%)和芳樟醇(69.6%)。对来自扁桃体组织的几种细菌进行了抗菌活性评估。研究了EOs对金黄色葡萄球菌生物膜的活性，以及这些EOs与抗生素混合使用对金黄色葡萄球菌生物膜的作用。TBARS法测定两种提取物的抗氧化活性，野生牛至提取物表现出较好的抗氧化活性。此外，体外评估了EOs的细胞毒性，两种EOs都显示出抑制肿瘤细胞进一步增殖的潜力。本研究首次报道了EOs对慢性扁桃体炎病原体的作用，支持其作为一种天然生物活性治疗剂的作用，并可能应用于抗菌领域。

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来源期刊

Journal of Essential Oil Research 工程技术-食品科技

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

18-36 weeks

期刊介绍： Journal of Essential Oil Research ( JEOR) is the major forum for the publication of essential oil research and analysis. Each issue includes studies performed on the chemical composition of some of the 20,000 aromatic plants known in the plant kingdom. JEOR is devoted entirely to all phases of research from every corner of the world by the experts in their field. JEOR''s main areas of focus include: -Analytical chemistry- Biological activity- Biotechnology- Chemical composition- Chemical synthesis- Chemosystematics- Microbiological activity- Plant biochemistry/biosynthesis- Toxicology. Published six times per year, JEOR provides articles on the aromatic principles of a plant or its isolates and are directed toward furthering our readers'' knowledge of the aromatic plant and animal kingdoms.