Non-English primary language and disparities in stroke outcomes after mechanical thrombectomy: a single institution study

N. Karim, Suzanne Stone, A. Salter, M. Gebreyohanns, Mark D. Johnson, E. Jones
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Abstract

Delays in acute treatment of ischemic stroke have been associated with worse outcomes. While having a non-English primary language has not been shown to delay receiving thrombolytic therapy, we assessed whether non-English primary language was associated with worse functional outcomes in patients receiving mechanical thrombectomy (MT).This is a retrospective study of our MT database from two comprehensive stroke centers from January 2016 to May 2021. Primary endpoint was discharge modified Rankin Scale (mRS) 0-2. Differences between English primary language (EPL) and non-English primary language (nEPL) groups were evaluated using an analysis of variance (ANOVA), Kruskal-Wallis and chi square test. Multivariable logistic regression was used to evaluate EPL vs. nEPL patients using data driven models determined by stepwise selection approach.We identified 276 patients receiving MT with 83% EPL and 17% nEPL patients. nEPL patients had higher mean hemoglobin A1c, were less likely to have insurance, and more likely to have symptomatic intracranial hemorrhage compared to EPL patients (Table). We observed a longer median ED arrival to groin puncture time in the nEPL group. No differences were observed in discharge or mRS 0-2 in the univariate or multivariable logistic regression.Despite finding longer ED length of stay among nEPL patients, there was no difference between nEPL and EPL in good functional outcome rates in patients treated with MT.
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非英语母语和机械取栓后卒中结局的差异:一项单一机构研究
缺血性脑卒中的急性治疗延迟与较差的预后相关。虽然主要语言非英语并未显示延迟接受溶栓治疗,但我们评估了非英语主要语言是否与接受机械取栓(MT)的患者更差的功能结果相关。这是一项对2016年1月至2021年5月来自两个综合卒中中心的MT数据库的回顾性研究。主要终点为出院修正Rankin量表(mRS) 0-2。使用方差分析(ANOVA)、Kruskal-Wallis和卡方检验评估英语主要语言组(EPL)和非英语主要语言组(nEPL)之间的差异。采用逐步选择方法确定的数据驱动模型,采用多变量逻辑回归对EPL和nEPL患者进行评估。我们确定了276例接受MT的患者,其中83%为EPL, 17%为nEPL。与EPL患者相比,nEPL患者的平均血红蛋白A1c较高,投保的可能性较小,并且更容易出现症状性颅内出血(表)。我们观察到nEPL组ED到达腹股沟穿刺的中位时间更长。单因素和多因素logistic回归均未发现出院率和mRS 0-2的差异。尽管发现nEPL患者的ED住院时间更长,但nEPL和EPL在MT治疗患者的良好功能转成率方面没有差异。
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