Imagerie des pneumopathies médicamenteuses

Abstract

The frequency of drug-induced lung toxicity is increasing. Diagnosis is complex due to numerous involved drugs and to various anatomo-clinical manifestations. Radiograph and lung CT scans are important tools for the diagnosis. Drug-induced lung diseases mainly include oedema with or without diffuse alveolar damage, pulmonary hemorrhage, non specific interstitial pneumonia, organizing pneumonia, hypersensitivity reaction, eosinophilic pneumonia and obliterative bronchiolitis. For each of these manifestations, we reviewed the drugs most frequently involved, the radiographic appearance and CT findings. The main lung radiologic manifestations, were described in the most common drugs that cause lung toxicity such as bleomycin, busulfan, cyclophosphamide, methotrexate, amiodarone, nitrofurantoin, gold salts and minocycline.