Crosstalk between oxidative stress and ocular diseases

Abstract

Context: Diverse findings reported during the past years has established the molecular mechanisms by which a disparity in the redox balance system in microenvironment and cells with high grade of Oxidative Stress (OS) can cause oxidation of macromolecules as nucleic acids, lipids, proteins and carbohydrates, thus bringing about their function alteration. These events also result in modulation of redox circuits herein signal transduction pathways and activation of transcription factors that can lead to chronic inflammation and contribute to several chronic diseases, including eye diseases and retinopathy.