Enriching miRNA binding site specificity with sequence profile based filtering of 3'-UTR region of mRNA

Jasjit K. Banwait, H. Ali, D. Bastola
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Abstract

MicroRNAs are small (approx. 22nt) noncoding RNAs that regulate gene expression by either degrading messenger-RNA (mRNA) that has already been transcribed or by repressing the translation of mRNA. This mechanism of gene regulation by binding of the miRNA to 3-prime-UTR of target mRNAs has been recently discovered and sequence-specific post-transcriptional gene regulation process affects large set of genes involved in number of biological pathways. Mapping of 7nt long miRNAseed sequence to the target gene has been a standard way of predicting miRNA targets. In this study, we have generated a profile-based filter to increase the specificity of human miRNA-mRNA relationship thereby enriching true-positive miRNA target sitesin humans based on sequence information.
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利用基于序列谱的mRNA 3′-UTR区域过滤来增强miRNA结合位点特异性
microrna很小(约为。通过降解已转录的信使rna (mRNA)或抑制mRNA的翻译来调节基因表达的非编码rna。这种通过miRNA结合靶mrna的3-prime-UTR进行基因调控的机制最近才被发现,序列特异性的转录后基因调控过程影响了大量涉及多种生物学途径的基因。将7nt长的miRNAseed序列定位到靶基因已成为预测miRNA靶标的标准方法。在本研究中,我们生成了一个基于谱的过滤器,以提高人类miRNA- mrna关系的特异性,从而根据序列信息丰富人类miRNA真阳性靶点。
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