Evaluation of Serum Levels of Vitamin D in Patients with Vitiligo: A Case-Control Study

Abstract

Introduction: Vitiligo is an autoimmune disease that is caused by the destruction of melanocytes and is appeared as depigmented patches on skin and mucosa. There have been various reports of serum Vitamin D levels in patients with vitiligo. The present study aimed to Evaluation of serum Vitamin D levels in patients with vitiligo. Material and Methods: A case-control study was performed on 138 samples among people referring to Sabzevar Vasei clinic in the period of 2018-2019. The research units meeting the inclusion criteria were selected using convenience sampling and then divided into two group case and control (69 patients and 69 healthy people). After obtaining informed consent and completing the checklist of demographic characteristics, blood samples were taken from both groups and serum levels of Vitamin D in both groups were evaluated and compared. Data were analyzed using SPSS 20 via the independent t-test, chi-square test, Mann-Whitney test, Spearman correlation at a significance level of less than 0.01. Results: In total, 131 participants completed the study; the two groups did not differ significantly in terms of age nor gender. At the end of the study, the mean of serum levels of Vitamin D in was significantly lower in the patients with vitiligo than in the people without vitiligo (P <0.001). Conclusion: The results showed that serum Vitamin D levels in patients with vitiligo are lower than in those who do not have vitiligo. Therefore, it is recommended to measure the serum level of Vitamin D in these patients and if it is low, a treatment regimen should begin for these patients.