S. Diwakarla, D. Finkelstein, Remy Constable, O. Artaiz, M. D. Di Natale, R. McQuade, Enie Lei, Xin-Yi Chai, M. Ringuet, L. Fothergill, V. Lawson, L. Ellett, Joel P. Berger, J. Furness
{"title":"Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson’s disease","authors":"S. Diwakarla, D. Finkelstein, Remy Constable, O. Artaiz, M. D. Di Natale, R. McQuade, Enie Lei, Xin-Yi Chai, M. Ringuet, L. Fothergill, V. Lawson, L. Ellett, Joel P. Berger, J. Furness","doi":"10.1111/nmo.13755","DOIUrl":null,"url":null,"abstract":"Chronic stress exacerbates motor deficits and increases dopaminergic cell loss in several rodent models of Parkinson's disease (PD). However, little is known about effects of stress on gastrointestinal (GI) dysfunction, a common non‐motor symptom of PD. We aimed to determine whether chronic stress exacerbates GI dysfunction in the A53T mouse model of PD and whether this relates to changes in α‐synuclein distribution.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurogastroenterology & Motility","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/nmo.13755","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
Chronic stress exacerbates motor deficits and increases dopaminergic cell loss in several rodent models of Parkinson's disease (PD). However, little is known about effects of stress on gastrointestinal (GI) dysfunction, a common non‐motor symptom of PD. We aimed to determine whether chronic stress exacerbates GI dysfunction in the A53T mouse model of PD and whether this relates to changes in α‐synuclein distribution.
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