Head-to-Head Comparison of Bi- and Nonavalent Human Papillomavirus Vaccine-Induced Antibody Responses.

IF 3.6 4区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Italian Journal of Food Science Pub Date : 2022-09-28 DOI:10.1093/infdis/jiac190
Laila Sara Arroyo Mühr, Carina Eklund, Camilla Lagheden, Tiina Eriksson, Ville N Pimenoff, Penelope Gray, Matti Lehtinen, Joakim Dillner
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Abstract

For head-to-head comparison of human papillomavirus (HPV) antibody levels induced by different vaccines, 25-year-old vaccine-naive women were given either the bivalent (n = 188) or the nonavalent HPV vaccine (n = 184). Six months after vaccination antibodies against pseudovirions from 17 different HPV types (HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68/73) were measured. Antibodies against HPV16/18 were higher after bivalent HPV vaccination (mean international units [IU] 1140.1 and 170.5 for HPV16 and 18, respectively) than after nonavalent vaccination (265.1 and 22.3 IUs, respectively). The bivalent vaccine commonly induced antibodies against the nonvaccine HPV types 31/33/35/45 or 58. The nonavalent vaccine induced higher antibodies against HPV6/11/31/33/45/52/58 and 35.

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双价和无价人类乳头状瘤病毒疫苗诱导抗体反应的头对头比较。
为了对不同疫苗诱导的人类乳头瘤病毒 (HPV) 抗体水平进行头对头比较,25 岁的疫苗免疫未接种女性接种了二价 (n = 188) 或无价 HPV 疫苗 (n = 184)。接种六个月后,测量了针对 17 种不同 HPV 类型(HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59/66/68/73)假病毒的抗体。接种二价 HPV 疫苗后,HPV16/18 的抗体(HPV16 和 18 的平均国际单位 [IU] 分别为 1140.1 和 170.5)高于无价疫苗(分别为 265.1 和 22.3 IU)。二价疫苗通常能诱导出针对未接种疫苗的 31/33/35/45 或 58 型 HPV 的抗体。二价疫苗可诱导出较高的 HPV6/11/31/33/45/52/58 和 35 型抗体。
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来源期刊
Italian Journal of Food Science
Italian Journal of Food Science 工程技术-食品科技
CiteScore
4.20
自引率
0.00%
发文量
33
审稿时长
>36 weeks
期刊介绍: "Italian Journal of Food Science" is an international journal publishing original, basic and applied papers, reviews, short communications, surveys and opinions on food science and technology with specific reference to the Mediterranean Region. Its expanded scope includes food production, food engineering, food management, food quality, shelf-life, consumer acceptance of foodstuffs, food safety and nutrition, energy and environmental aspects of food processing on the whole life cycle. Reviews and surveys on specific topics relevant to the advance of the Mediterranean food industry are particularly welcome.
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