Fast purinergic transmission in the central nervous system

Seminars in Neuroscience Pub Date : 1996-08-01 DOI:10.1006/smns.1996.0029

Alasdair J. Gibb, Fiona C. Halliday

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引用次数: 38

Abstract

Fast synaptic transmission mediated by P_2XATP receptors is a recent discovery in the central nervous system and new information on the distribution of P_2Xbinding sites and mRNA for P_2Xreceptor subunits in the brain suggests that transmission mediated by ATP may be widespread. P_2XATP receptors have many functional similarities to other receptors mediating fast excitatory synaptic transmission and some significant differences. ATP release is calcium-dependent and vesicular in nature. Individual synaptic currents are small in size (around 10 pA at −70 mV), have a fast rise-time and decay with a time-course (decay tau = 18 ms at −70 mV) intermediate between that of AMPA receptor-mediated synaptic currents and NMDA receptor-mediated synaptic currents. It is likely that P_2XATP receptor channels are permeable to calcium suggesting by analogy with glutamatergic transmission that purinergic transmission will participate in the regulation of calcium-dependent processes in neurones.

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嘌呤能在中枢神经系统中的快速传递

P2XATP受体介导的快速突触传递是最近在中枢神经系统中发现的，关于p2x结合位点和p2x受体亚基mRNA在大脑中分布的新信息表明，ATP介导的传递可能是广泛存在的。P2XATP受体与其他介导快速兴奋性突触传递的受体在功能上有许多相似之处，但也有一些显著差异。ATP的释放是钙依赖性和囊泡性的。单个突触电流体积小(−70 mV时约为10 pA)，上升时间快，衰减时间(−70 mV时衰减τ = 18 ms)介于AMPA受体介导的突触电流和NMDA受体介导的突触电流之间。P2XATP受体通道可能对钙具有渗透性，与谷氨酸能传递类似，嘌呤能传递参与神经元钙依赖过程的调节。

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Seminars in Neuroscience

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