Extract of Glycyrrhiza glabraroot attenuates nociception in experimental pain models: The role of BKCa channels

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-01-01 DOI:10.37360/blacpma.22.21.4.29

A. Parlar, Rabia Edibe Parlar Koprulu, S. Arslan, S. Cam, Fidan Pesen Ozdogan, O. Yumrutas, F. Uckardes, Miguel Rios, Jose L. Martinez

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引用次数: 3

Abstract

The aim of this study was to evaluate the functional interaction of Glycyrrhiza glabraroot extract (GGRE) on the large conductance Ca2+-activated K+(BKCa) channels expressed in the peripheral nervous system by using nociception and inflammation models in rodents in vivo. Besides toxicity studies and open field tests, nociception and inflammation tests were performed on rodents. Different doses of GGRE were given orally to rats and mice. Naloxone, indomethacin, morphine, NS1619 and iberiotoxin (IbTX) were administered. GGRE had both anti-nociceptive and anti-inflammatory activity in rats and mice. GGRE exhibited an analgesic effect by decreasing the time-course of the pain threshold or reaction time insome nociceptive tests. Furthermore, GGRE reduced level of pro-inflammatory cytokines, including TNF-α and IL-1β. As a conclusion, GGRE can alleviate the pain sensation of the afferent nerves and can reduce inflammation and associated pain by activating BKCa channels and reducing the levels of TNF-α, IL1β.

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甘草提取物减轻实验性疼痛模型中的伤害感受:BKCa通道的作用

本研究的目的是通过啮齿动物体内伤害和炎症模型，评估甘草提取物(GGRE)对外周神经系统表达的大电导Ca2+激活K+(BKCa)通道的功能相互作用。除毒性研究和野外试验外，还对啮齿动物进行了伤害感受和炎症试验。给大鼠和小鼠口服不同剂量的GGRE。给予纳洛酮、吲哚美辛、吗啡、NS1619和iberiotoxin (IbTX)。在大鼠和小鼠中均具有抗伤害和抗炎活性。在一些伤害性测试中，GGRE通过降低痛阈的时间过程或反应时间而表现出镇痛作用。此外，GGRE降低促炎细胞因子水平，包括TNF-α和IL-1β。综上所述，GGRE可通过激活BKCa通道，降低TNF-α、il - 1β水平，减轻传入神经的痛感，减轻炎症及相关疼痛。

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.